Services & Support Available:
- Study design assistance: we can provide recommendations for specimen sampling time, suitable specimen collection/processing methods, and relevant biomarkers to assess.
- Biomarker measurements (these are dependent and species and type of specimen) include but are not limited to:
a. Hepatic: miR-122, total HMGB1, full length and caspase cleaved K18, GLDH, total bile acids, ALT, AST, ALP, total and direct bilirubin, LDH, albumin, and microRNA profiling
b. Renal: KIM-1, clusterin, albumin, total protein, cystatin c, RPA-1, β2-microglobulin, osteopontin, NGAL, GSTα, GSTµ- sCr, and BUN
c. Cardiac: cTnT, cTnI, hFABP, BNP, NT-proBNP, CK-MB, LDH, and AST, and microRNA profiling
- Data Analysis/Interpretation
- Access to in silico modeling that incorporates release and clearance kinetics to improve study design and data interpretation (liver only at present)