The Organ Injury Biomarker Core is a full service core designed to assist researchers in study design, quantification, and interpretation of recently discovered biomarkers of organ injury with a primary focus on the liver, kidney and heart. The traditional biomarkers utilized for detection of hepatic, renal, and/or cardiac injury are suboptimal, lacking sensitivity and specificity. Newer biomarkers not only provide enhanced sensitivity and specificity for injury detection but additionally provide insight into mechanism of injury. Although we currently are focusing on liver, kidney, and cardiac injuries in clinical and nonclinical specimens, we are willing to expand our menu of assays to include other organs based on the needs of the researchers we serve. Please contact us with any questions or suggestions.
For a limited time, we are accepting 1 page proposals to initiate collaborations in which biomarker measurements, analyses, and interpretations will be conducted by our core for little to no cost to researchers (up to a maximum of $2000 in consumables supplied). We are seeking projects in which liver, renal, or cardiac injury are suspected in clinical or nonclinical studies but have not yet been explored with the offered biomarkers. Please contact us for more details or to submit a proposal. Funding decision will be made within 2 weeks of submission.
Now offering MicroRNA Profiling
MicroRNAs are small, noncoding RNA species that post-transcriptionally regulate gene expression. These species make ideal biomarkers because they are highly stable in biofluids, such as blood and urine, and can be released into circulation following organ injury. Utilizing minimal sample volume, we can now profile targeted panels (68-plex) of microRNAs in a high throughput format.
MicroRNA panels are available for the following areas of interest:
- Liver Toxicology